IL6 and idiopathic pulmonary fibrosis: Accumulating evidence indicates that senescent cells are metabolically active and secrete a large number of leukocyte mediators, including interleukin (IL)-1β, IL-6, and IL-8, which induce the differentiation of lung fibroblasts into myofibroblasts, thereby promoting IPF onset (Sugihara et al., 2020; Xu et al., 2020).