DDIT3 and colon adenocarcinoma: The multivariate survival analysis showed that patients with COAD with high expression of alanyl-tRNA synthetase 1 (AARS1) (Adjusted HR = 1.583, 95%CI = 1.043–2.401, p = 0.031) or DNA damage inducible transcript 3 (DDIT3) (Adjusted HR = 1.556, 95%CI = 1.013–2.390, p = 0.044) had worse OS when compared with patients with low expression of DDIT3 or AARS, respectively (Figures 4B,C; Table 2).