The transcription factor ATF4 drives the expression of ULBP1 gene in cancer cells, while the RNA binding protein RBM4 supports the expression of ULBP1 by inhibiting a new alternative splicing subtype of ULBP1 mRNA, and explains its mechanism of activating the body’s immune system (Gowen et al., 2015). The gene discussed is RBM4; the disease is cancer.