Interestingly, a study of 462 primary colorectal tumors by McGilvray et al. investigated the ULBP1-expressed protein in different TNM stages, the result showed the opposite trend was that high expression level of ULBP1 was common in TNM stage I tumors, but gradually decreased in stage II, III, and IV tumors (McGilvray et al., 2009). The gene discussed is ULBP1; the disease is colorectal neoplasm.