These CAR-T cells showed more immature phenotypes (expressing high levels of CD62L and CD45RA), as compared to conventional CD19-BBz-CAR T cells, an increased production of IL-2 and greater expansion in culture, as well as improved anti-tumor efficacy (increased persistence, infiltration and eradication of lymphoma distant metastasis) upon adoptive transfer in immunodeficient mice (74). This evidence concerns the gene IL2 and lymphoma.