Similar results have been published by Guo et al. with PD-1 KO GPC3-specific CAR-T cells in a HCC preclinical study (288), and Choi et al. with PD-1 KO EGFRvIII-specific CAR-T cells in a glioblastoma preclinical study (289). Here, GPC3 is linked to glioblastoma.