Prostate-specific membrane antigen (PSMA) is another transmembrane protein highly expressed on the tumor-associated endothelium of a great variety of solid tumors - including bladder, oral, hepatocellular, gastric, colorectal, breast, ovarian, renal, and pancreatic ductal carcinoma as well as NSCLC and melanoma - (96, 97). This evidence concerns the gene FOLH1 and neoplasm.