CXCR3 and neoplasm: This is proven by an increased expression of CXCL9 and CXCL10 by myeloid cells within the TME, with increased recruitment of CXCR3+ TH1 to the tumor as well as by the enhanced expression of genes associated with M1-like macrophages and a marked loss of genes associated with M2-like macrophages and MDSC-like cells (201).