TGFB1 and neoplasm: Strategies to overcome immunosuppressive impact of the Treg population can be resumed as follows: (i) depletion strategies aiming to reduce cellular density of Tregs in the tumor, (ii) expression of interleukin receptors, hybrid interleukin receptors or switch receptors (iii) optimization of costimulatory domains of CAR-T cell, (iv) transgenic production of various cytokines by TRUCKs and, not least, (v) shielding of CARs from the suppressive effect of TGF-β by gene editing (Figure 5).