CD4 and neoplasm: In addition to ESTIMATE, CIBERSORT and CIBERSORTx, other commonly used tools include Microenvironment Cell Populations (MCP)-counter, which computes an abundance estimate of eight different immune cell types and two stromal cells (fibroblasts and endothelial cells) (207); as well as the webtool Tumor IMmune Estimation Resource (TIMER), which provides the proportions of six immune cells, CD4+ and CD8+ T cells, B cells, DCs, macrophages, and neutrophils in the tissue of 23 tumor types from The Cancer Genome Atlas (TCGA) (208).