Furthermore, the addition of soluble ULPB4 to CD8+ T cells from MS patients co-cultured with astrocytes enhanced the production of inflammatory cytokines and increased T cell motility, thus suggesting an important contribution of the crosstalk between CD8+ T cells and astrocytes in synergy with CD4+ Th cells to CNS damage in MS (153). Here, CD4 is linked to myeloid sarcoma.