In C57BL/6-lpr/lpr mice, that develop a progressive lymphoproliferative syndrome followed by severe autoimmune disease and lupus nephritis, IL-1R8 deficiency was associated with higher activation of DCs and expression of IL-6, IFNβ, TNF, IL-12, and B cell survival factors Baff/BlyS and Bcl-2, as well as production of lupus autoantibodies (141). This evidence concerns the gene SIGIRR and systemic lupus erythematosus.