SIGIRR and colitis: In a murine model of dextran sulfate sodium (DSS)-induced colitis, IL-1R8 deficiency is associated with increased local leukocyte infiltration and higher levels of proinflammatory cytokines (TNFα, IL- 6, IL- 1β, IL- 12p40, IL- 17), chemokines (CXCL1, CCL2), and prostaglandins, leading to an exacerbated intestinal inflammation.