The phenotype of IL-1R8-deficient neurons was associated with IL-1R1-driven hyperactivation of the PI3K/AKT/mTOR pathway, and increased expression of methyl-CpG-binding protein 2 (MeCP2), a synaptopathy protein involved in neurological diseases, such as Rett syndrome and MeCP2 duplication syndrome (168). The gene discussed is MECP2; the disease is atypical Rett syndrome.