Importantly, transgenic mice expressing this mutant form of IL-1R8 in the colonic epithelium are more susceptible to colon cancer development in the colitis-associated tumor model, presenting higher local levels of inflammatory cytokines (IL-17A and IL-6) and the activation of transcription factors STAT3 and NF-κB. This evidence concerns the gene SIGIRR and malignant colon neoplasm.