In veterinary medicine, several reports show the expression and relevance of IL-1R8 in inflammatory and infectious conditions, including infection by porcine circovirus 2 in pigs (127) and Staphylococcus aureus mastitis in goat (128), inflammation in forestomach wall and mammary cells of ruminants (129–131), or intestinal epithelial cells and APCs from Peyer’s patches in pigs (132–134). The gene discussed is SIGIRR; the disease is infection.