Deficiency of IL-1R1 or treatment with IL-1Ra (Anakinra) normalized MeCP2 expression and cognitive deficits in IL-1R8-deficient mice, demonstrating that IL-1R8 fine tunes IL-1R1 signalling, is involved in synaptopathies and is required for correct long-term potentiation (107). The gene discussed is SIGIRR; the disease is Cognitive impairment.