In contrast with these results, in a house dust mite (HDM) asthma model, which relies on the activation of TLR4 on epithelial cells and subsequent exacerbated Th2 specific response, IL-1R8-deficiency was associated with decreased production of Th2 cytokines in lung and draining lymph nodes, reduced eosinophilic inflammation, mucus production by goblet cells, HDM-specific IgG1 and airway hyperreactivity compared with wild type mice. This evidence concerns the gene SIGIRR and asthma.