Several studies showed that IL-1R8 is necessary for the anti-inflammatory potential of IL-37 in different pathologic conditions, including LPS-induced endotoxemia, Aspergillus fumigatus pulmonary infection (11, 117), allergic responses (118), neuroinflammatory diseases, such as multiple sclerosis (119) or spinal cord injury (120), and DSS-induced colitis (121). This evidence concerns the gene SIGIRR and colitis.