According to these results, RNAseq analysis in 1102 clinical samples of breast tumors revealed that high IL-1R8 expression was associated with a non-T cell inflamed molecular signature, lower expression level of proinflammatory cytokines and chemokines, DC and NK cell metagenes, components of the peptide presenting machinery, cytolytic enzymes and type I interferon (IFN)-induced genes (151). The gene discussed is SIGIRR; the disease is breast neoplasm.