CDH11 and pulmonary fibrosis: While our in vitro data suggests that CDH11 may regulate the M2 phenotype of macrophages, our in vivo data argues against an exclusive role for regulation of M2 polarization by CDH11 in the pathogenesis of pulmonary fibrosis and suggests that regulation of monocyte-derived macrophage development by CDH11 is more likely a component of the mechanism of lung fibrosis.