Furthermore, APOE allele ε4 appeared to increase the risk of developing CAD without or with T2DM, with adjusted OR of 1.72 (95% CI, 1.22–2.42) and 1.97 (95% CI, 1.32–2.93), respectively, compared with the allele ε3. This evidence concerns the gene APOE and type 2 diabetes mellitus.