After adjusting for maternal age, maternal BMI, type of infertility, basal FSH, AMH, number of transferred embryos, type of transferred embryos, and number of intrauterine procedures, multivariable logistic analysis showed that a multiple number of intrauterine procedures was an independent risk factor for PROM in RIF patients (aOR 1.537; 95% CI: 1.105–2.137; P = 0.014), as show in Table 3. This evidence concerns the gene BRD2 and Infertility.