CFTR and allergic disease: Effects of scoparone have been observed in many other systems and models, including immunosuppressive functions associated with autoimmunity, allergies, and graft rejection (159, 160); neurite outgrowth and dopamine synthesis and release in the PC12 neuronal cell line (161–163); proliferation and migration of cancer cells (105, 164); bactericidal, antifungal, and antiparasitic properties (165–167); promotion of melanogenesis; and activation of the cystic fibrosis transmembrane conductance regulator (CFTR) (168, 169).