By injecting IL-17 blocking antibody into apolipoprotein E deficient (apoE−/−) mice, it was discovered that functional blocking of IL-17 could decrease atherosclerotic lesions and improve as well as decrease plaque vulnerability, cell infiltration, and tissue activation, proposing that IL-17 plays a vital role in atherosclerosis formation (Erbel et al., 2009). This evidence concerns the gene IL17A and atherosclerosis.