Despite that anthracyclines induce mitochondrial dysfunction and energy deficiency, which are supposed to stimulate AMPK signalling, many studies revealed that AMPK as well as its downstream target acetyl-CoA carboxylase (ACC) are indeed inhibited by anthracyclines (Gratia et al., 2012; Kawaguchi et al., 2012; Wang et al., 2012). This evidence concerns the gene PRKAA1 and hyperinsulinemic hypoglycemia, familial, 4.