As expected, plasma from COVID-19 patients significantly increased the number of TFpos- and P-selectinpos-platelets (Figure 1) and the formation of total and TFpos platelet–monocyte and platelet–granulocyte aggregates (Figure 2) as well as the release of total and platelet-derived TFpos circulating MVs (Figure 3), highlighting the marked prothrombotic phenotype associated with both TF-bearing cells and MVs. This evidence concerns the gene TF and COVID-19.