COVID-19 is characterized by an overwhelming state of inflammation with an elevated level of circulating chemokines (e.g., MCP-1 and RANTES) and cytokines, such as IL-6, IL-8, and TNF-α eventually leading to a multi-organ dysfunction that has been called COVID-19 cytokine storm syndrome (CSS) (England et al., 2021). The gene discussed is CXCL8; the disease is COVID-19.