In fact, while the exact mechanism by which adenovirus-vectored COVID-19 vaccines trigger the vaccine-induced immune thrombotic thrombocytopenia (VITT) is still unclear; this syndrome is thought to involve a FcγRIIA receptors-dependent platelet activation causing platelet P-selectin’s expression, secretion of alpha granules, and release of procoagulant MVs, leading to TF accumulation into developing thrombi (Marchandot et al., 2021). Here, SELP is linked to COVID-19.