CRP and Disorder of lipid metabolism: Besides, some stress reaction followed stroke may lead to the neuronal expression of monomeric C-reactive protein, which act as a sensor for systemic inflammation and played an important role in the late degeneration of brain tissues (Slevin et al., 2020); (3) patients with AIS are mostly associated with lipid metabolism disorders, increased LDL, and increased blood lipids, which could cause endothelial cell damage and aggravate inflammatory and stress responses.