Previous studies have demonstrated that the poor clinical outcome following thrombolytic therapy with r-tPA for patients with AIS was associated with an elevated random blood glucose (RBG) concentration drawn on admission or an elevated fasting blood glucose (FBG) concentration (Capes et al., 2001), both of which had limitations in distinguishing chronic poor management of background glucose levels and physiological stress response to AIS. The gene discussed is PLAT; the disease is androgen insensitivity syndrome.