Besides, some stress reaction followed stroke may lead to the neuronal expression of monomeric C-reactive protein, which act as a sensor for systemic inflammation and played an important role in the late degeneration of brain tissues (Slevin et al., 2020); (3) patients with AIS are mostly associated with lipid metabolism disorders, increased LDL, and increased blood lipids, which could cause endothelial cell damage and aggravate inflammatory and stress responses. This evidence concerns the gene CRP and Stroke.