However, chronic hyperglycemia might make the neuroendocrine system less sensitive during the acute phase of stroke through downregulation of glucose transporters (Dungan et al., 2009), and consequently alter the association between stress hyperglycemia and stroke outcomes; (2) stress hyperglycemia may give rise to reperfusion injury after r-tPA intravenous thrombolysis by increasing oxidative stress and inflammation (Luitse et al., 2012; Koracevic, 2016). This evidence concerns the gene PLAT and Stroke.