APP and Alzheimer disease: Broadly speaking, these studies have employed various AD transgenic mouse models (e.g., 3xTg, APP/PS1, Tg2576, PS19, APP knockin) in the context of numerous injury systems [e.g., controlled cortical impact (CCI), midline fluid percussion injury (mFPI), lateral fluid percussion injury (LFPI), closed head impact model of engineered rotational acceleration (CHIMERA)].