MAPT and Alzheimer disease: Moving forward, given that phenotypes such as elevated Aβ peptides and tau hyperphosphorylation are readily observed in AD hiPSC lines (Israel et al., 2012; Kim et al., 2015; Jones et al., 2017), future studies could employ these cell lines to investigate the effect of cell injury on the induction or augmentation of AD-related molecular, biochemical, and cellular changes.