GFAP-positive reactive astrogliosis were observed not only in APP transgenic mice but also in other animal models such as doxycycline inducible astrocytic MAO-B transgenic mice (Mallajosyula et al., 2008), ischemia models (Boutin et al., 2015), LPS-injected animals (Ory et al., 2015), tau transgenic mice (Ramsden et al., 2005), and APP knock-in mice (Saito et al., 2014). This evidence concerns the gene APP and ischemia.