CREB1 and neoplasm: AFH is now recognized as a translocation associated neoplasm and is associated with three translocations EWSR-CREB1, EWSR-ATF1, and FUS-ATF1.5-7 EWSR-CREB1 is the frequently described aberration which is documented in more than 90% cases but is not specific as it is also seen in other tumours like clear cell sarcoma, clear cell sarcoma like tumours of the gastrointestinal tract, hyalinizing clear cell carcinomas and primary pulmonary myxoid sarcomas.9,10