KCNN2 and Parkinson disease: We found reduced IAHP currents in LC neurons of two different PD models, which is in perfect agreement with studies reporting (1) that genetic deletion in the SK2 gene reduces IAHP, resulting in a PD mouse model40 and (2) that heterozygous loss-of-function mutations (haploinsufficiency) in KCNN2, encoding SK2, lead to novel autosomal dominant neurodevelopmental movement disorders41.