DYRK1A, which is located on chromosome 21, is also involved in some possible tumor-controlling mechanisms such as promoting cell cycle exit through DREAM complex assembly45, controlling the expression of RE1 silencing transcription factor (REST)46, which is a tumor suppressor gene for mammary epithelial cell transformation47, colon cancer47 and lung cancer48. The gene discussed is ENSG00000279284; the disease is neoplasm.