The treatment of 18β-GA reduced IL-5, IL-13, TNF-α, OVA-specific IgE level and total IgE level while increased IFN-γ level, thereby helping to reduce the influx of leukocytes, goblet cell metaplasia, and airway hyperresponsiveness, as shown by lung histopathological analysis. The gene discussed is TNF; the disease is airway hyperresponsiveness.