Furthermore, Kaplan–Meier survival analysis also showed that patients with high levels of RFC2 in GBM (P = 0.014) (Fig. 4B), LGG (P < 0.001) (Fig. 4C), ACC (P < 0.001) (Fig. 4D), KICH (P = 0.022) (Fig. 4F), KIRC (P = 0.018) (Fig. 4G), LUAD (P = 0.01) (Fig. 4H), and UVM (P < 0.001) (Fig. 4I) had an apparently worse OS. Here, RFC2 is linked to glioblastoma.