Clinicopathological assessment illustrated that hsa_circ_0001394 expression was significantly correlated with tumor differentiation, vascular invasion, and AFP levels, suggesting that hsa_circ_0001394 expression may be correlated with HCC prognosis and might function as a noninvasive biomarker for the early detection and prognosis prediction of HCC in patients. The gene discussed is AFP; the disease is hepatocellular carcinoma.