We analyzed the results of RNA-seq and found that knocking down PCLAF in neuroblastoma can reduce the mRNA expression levels of some genes in the DREAM complex, such as FOXM1, CCNA2, BUB1, CCNB2, PLK1, CCNB1 and B-MYB, indicating the DREAM complex also played a part in the PCLAF regulation of neuroblastoma G1/S process. The gene discussed is CCNB1; the disease is neuroblastoma.