CCNE2 and neuroblastoma: The decrease in PCLAF gene expression significantly downregulated CyclinA2, CyclinB1, CyclinD1, CyclinE2, CDK2, and CDK6 (Fig. 2G, Supplementary Fig. 2A, B), which further showed that downregulation of PCLAF can inhibit the proliferation of neuroblastoma.