PIK3CA and esophageal squamous cell carcinoma: We found recurrent promoter or gene-body DMCs (each in >51% (46/91) patients) in 9 previously identified ESCC driver genes FAT1, NOTCH1, JUB, MLL2, PIK3CA, TGFBR2, NFE2L2, NOTCH3 and ZNF75025 (Fig. 3a; Supplementary Data S1).