Especially for CD4 + T cells, the expression of CBX1-7 members were all related to its infiltration: the expression of CBX3 was negatively related to its infiltration, while the expression of CBX1/2/4/5/6/7 was positively related to its infiltration, suggesting that CD4 + T cells may play an essential role in the CBX family’s influence on the immune status of GBM. This evidence concerns the gene CBX3 and glioblastoma.