Increased transcription also translated into 1.5- and 3.6-fold higher GAP-43 protein abundance in whole-mount immunolabeling of iWAT of LLC (Fig. 5C and SI Appendix, Fig. S5A) and C26 (Fig. 5D and SI Appendix, Fig. S5A) tumor-bearing cachectic compared with control and noncachectic tumor-bearing mice, respectively, indicating increased neurotrophic signaling and neurite outgrowth in iWAT of cachectic mice. Here, GAP43 is linked to neoplasm.