TNF and Cachexia: Inflammation plays an important role in the pathogenesis of many types of cachexia, including CAC, where mixtures of inflammatory cytokines, including TNFα and members of the IL-6 family (IL-6, LIF, and ciliary neurotrophic factor) and the TGF-β family (GDF-8, -11, and -15), as well as PTHrP are considered to elicit the wasting disorder (43).