When compared with control mice or C26nc tumor-bearing mice, LLC and C26 tumor-bearing mice exhibited drastically elevated plasma concentrations of IL-6 (4.5-fold for LLC and 48.8-fold for C26 tumor-bearing mice) and PTHrP (22-fold for LLC and 7.4-fold for C26 tumor-bearing mice), two proinflammatory cytokines that have been associated with beige adipogenesis in cachexia (3, 4) (Fig. 1 A and B). Here, IL6 is linked to neoplasm.