Increased local catecholamine concentrations accompanied a robust increase in protein abundance of the rate-limiting enzyme for catecholamine biosynthesis, tyrosine hydroxylase (TH), in iWAT and aWAT of cachectic LLC (1.5-fold in iWAT and 1.8-fold in aWAT) and C26 tumor-bearing mice (3-fold in iWAT and 1.5-fold in aWAT) compared with control or C26nc tumor-bearing mice (Fig. 3C). This evidence concerns the gene TH and neoplasm.