Our previous work, showing that β3-adrenoreceptor antagonism decreases WAT browning and ameliorates cachexia in the genetic keratin 5-son of sevenless (K5-SOS) model of CAC (3), argued for the involvement of β-adrenergic signaling in adipocytes during WAT browning causing the pathogenesis of CAC. The gene discussed is KRT5; the disease is Cachexia.