The exclusion of RNA from p62 oligomers that are formed upon activation of ZZ domain-mediated autophagic clearance would ensure efficient aggregate clearance even in situations when cellular levels of the vault RNA1–1 riboregulator are high, including for example some viral infections (Mrázek et al. 2007; Nandy et al. 2009; Amort et al. 2015; Li et al. 2015). This evidence concerns the gene SQSTM1 and viral infectious disease.