In particular, patients with GPVs in BRCA1 are associated with a family history of ovarian cancer (14.5% for BRCA1 carriers vs. 0.8% for non-carriers, p = 1.2 × 10− 15), more grade III (64.89% for BRCA1 carriers vs. 25.01% for non-carriers, p = 1.5 × 10− 20), more negative cases in ER, PR, and AR (71.76%, 70.99%, and 38.17% for BRCA1 carriers vs. 26.08%, 26.89%, and 7.46% for non-carriers, p = 4.1 × 10− 25, 2.6 × 10− 23, and 4.6 × 10− 21, respectively). Here, ESR1 is linked to ovarian cancer.