The probabilities generated by DrABC were distributed differently between non-carriers and patients with GPVs in any CPG (p = 2.0 × 10− 10; Fig. 3C) or BRCA1/2 (p = 7.8 × 10− 16; Fig. 3D and Additional file 13: Fig. S8), suggesting its capability in distinguishing patients with hereditary breast cancer. Here, BRCA1 is linked to Hereditary breast cancer.