TP53 and metastatic malignant neoplasm in the lymph nodes: Besides, patients with GPVs in other HRR-related genes are associated with a family history of pancreas cancer (9.3% in other HRR-related genes carriers vs. 1.5% in non-carriers, p = 4.3 × 10− 3) and more wild-type P53, while patients with GPVs in other CPGs are also associated with lymph node metastasis (Table 1).