HIP1R and thyroid cancer: Compared with the human normal thyroid epithelial cell line NTHY-ORI 3–1, mRNA and protein levels of HIP1R were both significantly upregulated in human papillary thyroid cancer cell line TPC-1, human poorly differentiated thyroid cancer cell line SW579, and human undifferentiated thyroid cancer cell line 8505C (Fig. 2A–C).