HIP1R and thyroid cancer: Based on the present study, we hypothesized that the upregulated HIP1R in thyroid cancer cells promoted cell proliferation through mediating endocytosis of PTEN, and flurbiprofen, a highly effective nonsteroidal anti-inflammatory drug (NSAID) inhibited the endocytosis by interrupting the interaction between HIP1R and PTEN, consequently attenuating the proliferation of thyroid cancer cells.