SNCA and stroke disorder: To further assess α-synuclein aggregation in the CNS of TgM83+/− mice after stroke, we stained coronal brain tissue sections of animals sacrificed at 360 days after MCAO or sham surgery by immunohistochemistry with three different antibodies, pSyn#64 (Fig. 6a–g), EP1536Y (Fig. 6h, i), and 81A (Fig. 6j, k), recognizing phosphorylated serine at position 129 of α-synuclein, which is associated with the cellular accumulation of pathologic α-synuclein deposits (Fig. 6) [17, 22, 33].