These indicators include the clinical parameters such as ECOG PS, non-adenocarcinoma histology, EGFR mutation and LENT score, the serum indicators such as NLR, hemoglobin, total protein, albumin, LDH, CRP and VEGF, and the pleural effusion indicators such as PH, glucose, LDH, VEGF and surviving. The gene discussed is VEGFA; the disease is adenocarcinoma.