Our findings suggest that for malignant patients with pleural effusion, LENT score and its items are valuable prognostic biomarkers, so do the clinical parameters like stage, distant metastasis, EGFR mutation, the serum biological parameters like hemoglobin, albumin, C-reaction protein, VEGF, and the pleural effusion biological parameters like PH, glucose, VEGF and survivin. The gene discussed is VEGFA; the disease is Pleural effusion.