ISLR and cancer: We recently screened a library of ligands of nuclear receptors for reagents that induce the upregulation of Meflin expression using CAFs derived from human PDAC and identified AM580 as a reagent that induces nearly 20-fold stronger expression of Meflin than a vitamin D derivative or all-trans retinoid acid (ATRA), which is known to have an ability to reprogram cancer stroma, similar to vitamin D derivatives [15].