Although the above-cited papers point toward a paramount role of CB1R signaling in slowing down the age-associated cognitive decline, some recent papers also suggest a possible involvement of CB2 receptors (CB2R), especially when considering “inflammaging”, which is the idea that aging is associated with a progressive decline in the ability to cope with stressors and a progressive increase in the whole-body load of proinflammatory cytokines [67]. This evidence concerns the gene CNR1 and Mental deterioration.