APOE and hyperlipidemia: The influence of APOE genotype on lipoprotein composition concentration is consistent with the mechanism of APOE gene polymorphisms associated with hyperlipidemia mentioned above, with ε2+ increasing the composition concentration of VLDL, IDL, and large LDL, and decreasing the composition concentration of small to medium LDL, whereas ε4+ increases the composition concentration of LDL.