INS and Hyperglycemia: While leucosceptoside A has benefits in traditional medicine for hyperglycemia and chronic diseases, it presented more significant binding energy (−7.5862 kcal/mol) and generated two hydrogen bonds with ASP282 (A) and ASP518 (A) residues in the vicinity of the active bonding cleft of the target protein, as well as one Pi interaction assisted by TRP376(A) residues, achieving a stable conformation in docked complex with a mechanism of α-glucosidase inhibition that assists the improvement of insulin secretion and manages blood glucose in diabetic patients.