They used toll-like receptor (TLR) ligands as adjuvants for maturation of DCs to activate danger signal-sensing pathways to gain the secretion of DEX with a higher capability to activate cytotoxic NK-cells and CD8+ T lymphocytes, which was combined with co-culture of DCs with oxidized necrotic B16F10 cells as the source of tumor antigens. Here, CD8A is linked to neoplasm.