In this work, we observed that knockout of the NADH dehydrogenase complex subunit genes NDUFB10, NDUFC2, NDUFC2-KCTD14, NDUFS8 led to a decrease in the sensitivity of MIA PaCa-2 pancreatic cancer cells to oxaliplatin. The gene discussed is NDUFS8; the disease is familial pancreatic carcinoma.