A lot of studies have been progressively focused on the identification and characterization of new wheat allergens involved in bakers’ allergies; although, not a single allergen emerged as major one due to the interindividual IgE-binding profile as shown in Table 1 [7,11,12,13,14,15,16,17,18,19,20,21,22]. This evidence concerns the gene IGHE and allergic disease.