Our data on the importance of 3, 3′- (3, 5-DCPBC) induced suppression of EGFR Y1086 phosphorylation is further underscored by the recent finding that growth hormone via EGFR and SRC kinases upregulates the transcription factor c-Kit for melanogenesis, and more importantly, that mutated Kit enforces MITF (Microphthalmia-associated transcription factor)-dependent transcription programs in melanoma [53,54]. The gene discussed is EGFR; the disease is melanoma.