AKT1 and hepatocellular carcinoma: Previously, DMC has been shown a role in compound-induced apoptosis and G0/G1 cell cycle arrest through the PI3K/AKT mitochondria-dependent pathway and increased generation of reactive oxygen species (ROS) as part of the apoptosis pathways in hepatocellular carcinoma (BEL-7402 and BEL-7402/5-FU cell lines).