In this study, we showed that a global absence of IFN-γ during T. cruzi infection (1) induced similar parasitemia and cytokine and chemokine levels (TNF-α, IL-6, IL-10, MCP-1, and IFN-γ) in WT and IFN-γ(−/−) infected mice in the early stage of infection and (2) delayed the onset of electromechanical remodeling in the LVC and RVC from the mice. Here, IL10 is linked to infection.