Moreover, it has been reported that known HCC driver genes, such as the telomerase reverse transcriptase (TERT), the lysine methyltransferase 2B (KMT2B—also known as MLL4), and the cyclin E1 (CCNE1), are affected by HBV integrations in HBV-HCC cases [26]. Here, CCNE1 is linked to hepatocellular carcinoma.