Our study results were comparable to those of Ghantous, who claimed that prolonged antibiotic treatment after orthognathic surgery didnot necessarily reduce the incidence of SSI [9].Those authors found no significant differences in the mean postoperative C-reactive-protein levels, body temperature, and infection rates between two groups of young, healthy patients, among whom one group received 1 g of intravenous amoxicillin–clavulanate three times a day for 5 days, and the second group received a placebo for the same period of time. The gene discussed is CRP; the disease is infection.