Regarding the inflammatory markers, the severe acute cholangitis group had significantly higher WBC (15,600 vs. 9655, p < 0.001), CRP (10.15 vs. 4.68, p = 0.001) and NLR (22.27 vs. 8.07, p < 0.001) than the mild/moderate acute cholangitis group. The gene discussed is CRP; the disease is acute cholangitis.