New therapies that have appeared in recent years or are still under investigation in ITP involve new TPO-RA (Avatrombopag, Lusutrombopag), tyrosine kinase inhibitors (Fostamatinib, Rilzabrutinib), and protease inhibitors (Bortezomib) [125]. Here, TPO is linked to autoimmune thrombocytopenic purpura.