Furthermore, CD74 immunohistochemical expression increased in higher-grade and late-stage metastatic invasive cancers compared to less aggressive and lower-grade cancers, as reported in thymic epithelial neoplasms [28], colorectal, gastric, and pancreatic cancers [29], and urothelial carcinoma of the bladder [17]. Here, CD74 is linked to familial pancreatic carcinoma.