Studies have shown the importance of systemic inflammation in the pathogenesis of COPD and some inflammatory biomarkers such as the neutrophil/lymphocyte ratio (NLR), uric acid, CRP (C-reactive protein), and procalcitonin (PCT), which are indicators of inflammation that are associated with the severity of the disease during the exacerbation period. This evidence concerns the gene CRP and chronic obstructive pulmonary disease.