Because immune checkpoint molecules such as the programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) system and the T-cell immunoglobulin and mucin domain-containing protein 3/Galectin-9 (TIM-3/Gal-9) system are decisive in the regulation of immune responses, we aim to highlight their role in the pathogenesis of preeclampsia in this review. The gene discussed is LGALS9; the disease is preeclampsia.