Because immune checkpoint molecules such as the programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) system and the T-cell immunoglobulin and mucin domain-containing protein 3/Galectin-9 (TIM-3/Gal-9) system are decisive in the regulation of immune responses, we aim to highlight their role in the pathogenesis of preeclampsia in this review. This evidence concerns the gene HAVCR2 and preeclampsia.