When the association between EZH2 expression and overall survival of HCC patients was investigated, the Kaplan–Meier analysis found that high expression of EZH2 was correlated with significantly poorer prognoses of patients with high EZH2 expression (χ2 = 16.10, p < 0.001) (Figure 1A). This evidence concerns the gene EZH2 and hepatocellular carcinoma.