Many OXLs derived via LOX pathway and/or auto-oxidative routes were lower in NASH-HIS, including TriHOMEs, 9- and 13-keto-octadecadienoic acid (-KODE), 9- and 13- hydroxyoctadecatrienoic acid (-HOTE), and 5-HETE. The gene discussed is LOX; the disease is metabolic dysfunction-associated steatohepatitis.